IRI:
http://safer-project.eu/SignalDetectorsOntology.owl
Version IRI:
http://safer-project.eu/SignalDetectorsOntology.owl/1.0.2

Abstract

This is an ontology developed in the scope of the SAFER (Semantic integrAtion and reasoning Framework for pharmacovigilancE signals Research) Marie-Curie fellowship project. The ontology aims to semantically describe signal detection methods and facilitate their selection and combinatorial exploitation in analysis experiments.

Table of Content

  1. Classes
  2. Object Properties
  3. Data Properties
  4. Named Individuals
  5. Annotation Properties
  6. Namespace Declarations

Classes

Administrative Claims Databasec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#AdministrativeClaimsDatabase

has super-classes
Observational Data Sourcec
has members
o m o p c c a eni, o m o p m d c dni, o m o p m d c rni, o m o p m s l rni

Analysis Criterionc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#AnalysisCriterion

A constraint/requirement that has been defined either implicitly (through computational inference) or explicitly (by the User) for an Analysis Experiment. It can be a Dataset, a Parameter, and an Analysis Experiment Target.

Example: “Decision Rule for Signal Generation in spontaneous reports datasets = More than 3 reports”.

is equivalent to
Analysis Experiment Targetc or Datasetc or Parameterc or Ranking Criterionc
is in domain of
hasValuedp, is defined forop, isComputeddp, isUserDefineddp
is in range of
containsop
is disjoint with
Analysis Experimentc, Performance Metricc, Pharmacovigilance Signalc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec

Analysis Experimentc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#AnalysisExperiment

A computational process involving the analysis of Datasets through the execution of at least one Signal Detector that is/are being launched according to a set of Analysis Criteria. Analysis Experiments are set-up by Users of the SAFER platform. Upon its execution, an Analysis Experiment is marked with the respective start and (potentially) end timestamp.

is equivalent to
(is set up byop some Userc) and (mayHaveop some Analysis Experiment Targetc) and (usesop some Datasetc) and (usesop some Signal Detectorc)
is in domain of
containsop, exploitsop, has performance metric valuedp, hasResultdp, is set up byop, mayHaveop, results inop, uses ranking criterionop, wasLaunchedOndp, wasTerminatedOndp
is in range of
is defined forop, is result ofop, isExploitedByop, mayBeSetForop, sets upop
is disjoint with
Analysis Criterionc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Analysis Experiment Targetc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#AnalysisExperimentTarget

A specific Drug (or Drug Class), Health Outcome or a pair “Drug – Health Outcome” that is being investigated in the scope of an Analysis Experiment for Pharmacovigilance Signal detection.

Example: “Acute Myocardial Infarction”, “Warfarin”, “Acute Myocardial Infarction - Warfarin”.

is equivalent to
Drugc or Health Outcomec or (Drugc and Health Outcomec)
is in domain of
mayBeSetForop
is in range of
mayHaveop
is disjoint with
Analysis Experimentc, Computing Environmentc, Datasetc, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Apply Leopard Filtering For Protopathic Biasc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ApplyLeopardFilteringForProtopathicBias

has super-classes
Parameterc
has members
apply leopard filtering for protopathic bias noni, apply leopard filtering for protopathic bias yesni

Bayesian Confidence Propagation Neural Networkc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#BayesianConfidencePropagationNeuralNetwork

has super-classes
Disproportionality based Signal Detection Methodc
has sub-classes
Bayesian Confidence Propagation Neural Network Extended To The Multiple Comparison Frameworkc, Original Bayesian Confidence Propagation Neural Network Originalc

Bayesian Confidence Propagation Neural Network Extended To The Multiple Comparison Frameworkc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#BayesianConfidencePropagationNeuralNetworkExtendedToTheMultipleComparisonFramework

has super-classes
Bayesian Confidence Propagation Neural Networkc

Case Control Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#CaseControlSignalDetectionMethod

has super-classes
Signal Detection Methodc
has members
o m o p c cni

Case-Control Matching Strategyc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#CaseControlMatchingStrategy

has super-classes
Parameterc
has members
case control matching strategy age and sexni, case control matching strategy age and sex and visit within 180dni, case control matching strategy age and sex and visit within 30dni

Clinical Narrativec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ClinicalNarrative

has super-classes
Free-text Data Sourcec

Cohort Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#CohortSignalDetectionMethod

has super-classes
Signal Detection Methodc
has members
o m o p c mni

Computational Ranking Criterionc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ComputationalRankingCriterion

A feature that is used to sort (and implicitly filter) the potential Pharmacovigilance Signals generated in the scope of an Analysis Experiment that is originated from the field of Computer Science.

Example: Precision at K.

has super-classes
Ranking Criterionc
has members
precision at kni, recall at kni

Computing Environmentc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ComputingEnvironment

The computational platform for which a particular Signal Detection Method is implemented to be executed at.

Examples: “C++”, “Java”, “R”, “SAS”.

is in domain of
executesop
is in range of
isImplementedForop
has members
c++ni, javani, matlabni, rni, s a sni
is disjoint with
Analysis Experimentc, Analysis Experiment Targetc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Control Related Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ControlRelatedParameter

has super-classes
Parameterc
has sub-classes
Control Periodc, Controls PerCasec, Include Index Date In Control Periodc, Use Control Period In Expected Calculationc

Controls PerCasec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ControlsPerCase

has super-classes
Control Related Parameterc
has members
up to 10 controls per caseni, up to 100 controls per caseni

Covariate Eligibility Windowc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#CovariateEligibilityWindow

has super-classes
Covariate Related Parameterc
has members
covariate eligibility window 180d prior to exposureni, covariate eligibility window 30d prior to exposureni, covariate eligibility window all time prior to exposureni, covariate eligibility window noneni

Covariate Related Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#CovariateRelatedParameter

has super-classes
Parameterc
has sub-classes
Additional Covariates Included In The Propensity Score Modelc, Covariate Eligibility Windowc, Covariate Selection Algorithm Additional Parametersc, Dimensions To Include As Potential Covariatesc

Datasetc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Dataset

A collection of data originated in the general case from a combination of Signal Sources. Datasets are is being explored in the scope of Analysis Experiments.

Example: “FAERS_ASCII_2013q3.zip and Warfarin_PubMed_Extract_2012-2014.txt”

has super-classes
originatesFromop some Signal Sourcec
is in domain of
originatesFromop
is in range of
contributesToop
is disjoint with
Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Decision Related Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DecisionRelatedParameter

has super-classes
Parameterc
has sub-classes
Decision Rule For The Signal Generationc, Threshold for Decisionc

Decision Rule For The Signal Generationc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Decision

has super-classes
Decision Related Parameterc
has members
decision equals 1 f d rni, decision equals 2 number of signalsni, decision equals 3 rank statni

Dimensions To Include As Potential Covariatesc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DimensionsToIncludeAsPotentialCovariates

has super-classes
Covariate Related Parameterc
has members
dimensions to include as potential covariates drugs and conditionsni, dimensions to include as potential covariates drugs conditions and proceduresni, dimensions to include as potential covariates drugs onlyni, dimensions to include as potential covariates noneni

Disproportionality based Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DisproportionalityBasedSignalDetectionMethod

has super-classes
Signal Detection Methodc
has sub-classes
Bayesian Confidence Propagation Neural Networkc, Gamma Poisson Shrinkage based Signal Detection Methodc, Proportional Reporting Ratio based Methodc, Reporting Fisher’s Exact Test Signal Detection Methodc, Reporting Odds Ratio based Methodc

Domain-specific Ranking Criterionc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DomainSpecificRankingCriterion

A feature that is used to sort (and implicitly filter) the potential Pharmacovigilance Signals generated in the scope of an Analysis Experiment that is originated from knowledge in the field of pharmacovigilance signal detection.

Examples: ADR unexpectedness, ADR seriousness.

has super-classes
Ranking Criterionc
has members
a d r seriousnessni, a d r unexpectednessni, events due to newer drugsni, events from mulitple countriesni, rapidly increasing disproportionalityni

Drugc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Drug

A pharmaceutical product (or class of products) that may be considered as the leading factor for unexpected Health Outcomes. It may be referred using standard terminologies/classifications, like ATC and RxNorm.

Examples: “Vioxx / ATC: M01AH02”, “Heparin / ATC: B01AB01”, “Proton-pump inhibitor / ATC: A02BC”.

is in domain of
hasATCcodedp, hasRXNORMcodedp
is disjoint with
Analysis Experimentc, Computing Environmentc, Datasetc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Electronic Health Recordc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ElectronicHealthRecord

has super-classes
Observational Data Sourcec
has members
o m o p g e centricityni

Exposures To Includec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ExposuresToInclude

has super-classes
Parameterc
has members
exposures to include all occurrencesni, exposures to include first occurrenceni

Free-text Data Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#FreeTextDataSource

An unstructured data repository that can be used for Pharmacovigilance Signal detection, e.g. social media content, clinical narratives and the literature.

has super-classes
Signal Sourcec
has sub-classes
Clinical Narrativec, Literature Sourcec, Social Media Sourcec

Gamma Poisson Shrinkage based Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#GammaPoissonShrinkageBasedSignalDetectionMethod

has super-classes
Disproportionality based Signal Detection Methodc
has sub-classes
Gamma Poisson Shrinkage Extended To The Multiple Comparison Frameworkc, Longitudinal Gamma Poisson Shrinkerc, Multi-item Gamma Poisson Shrinkerc, Original Gamma Poisson Shrinkagec

Gamma Poisson Shrinkage Extended To The Multiple Comparison Frameworkc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#GammaPoissonShrinkageExtendedToTheMultipleComparisonFramework

has super-classes
Gamma Poisson Shrinkage based Signal Detection Methodc

Health Outcomec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#HealthOutcome

An observation in the health condition of a subject due to an Adverse Drug Reaction. It may be expressed using standard terminologies such as UMLS, MedDRA (preferred terms), and LOINC (laboratory examination value ranges).

Example: “Gastrointestinal bleeding/hemorrhage / MedDRA: 10017936, 10005116”.

is in domain of
hasICD10codedp, hasICD9codedp, hasMedDRAcodedp
has members
acute liver injuryni, acute myocardial infarctionni, acute renal failureni, gastrointestinal bleedingni
is disjoint with
Analysis Experimentc, Computing Environmentc, Datasetc, Drugc, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Include All Drugs In A Multivariate Analysisc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#IncludeAllDrugsInAMultivariateAnalysis

has super-classes
Parameterc
has members
include all drugs in a multivariate analysis noni, include all drugs in a multivariate analysis yesni

Include Index Date In Control Periodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#IncludeIndexDateInControlPeriod

has super-classes
Control Related Parameterc
has members
include index date in control period noni, include index date in control period undefinedni, include index date in control period yesni

Include Index Date In Time At Riskc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#IncludeIndexDateInTimeAtRisk

has super-classes
Parameterc
has members
include index date in time at risk noni, include index date in time at risk yesni

International SRSc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#InternationalSRS

has super-classes
SRS Data Sourcec
has members
eu dra vigilanceni, vigi baseni

Literature Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#LiteratureSource

has super-classes
Free-text Data Sourcec
has members
pub medni, scopusni

Longitudinal Gamma Poisson Shrinkerc back to ToC or Class ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#LongitudinalGammaPoissonShrinker

has super-classes
Gamma Poisson Shrinkage based Signal Detection Methodc
has members
o m o p l g p sni

Minimum Number Of Notifications For A Couple To Be Potentially Considered As A Pharmacovigilance Signalc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MIN.n11

has super-classes
Parameterc
has members
m i n.n11 equals 1ni

Monte Carlo Simulation For Ranking Couplesc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MonteCarloSimulationForRankingCouples

has super-classes
Ranking Related Parameterc
has members
monte carlo simulation for ranking couples f a l s eni, monte carlo simulation for ranking couples t r u eni

Multi-item Gamma Poisson Shrinkerc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Multi-itemGammaPoissonShrinker

has super-classes
Gamma Poisson Shrinkage based Signal Detection Methodc

National SRSc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#NationalSRS

has super-classes
SRS Data Sourcec
has members
f a e r sni, larebni, yellow cardsni

Nesting Within Population With The Indication Of The Target Drugc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#NestingWithinPopulationWithTheIndicationOfTheTargetDrug

has super-classes
Parameterc
has members
nesting within population with the indication of the target drug noni, nesting within population with the indication of the target drug yesni

Number Of Monte Carlo Simulations For Ranking Couplesc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#NumberOfMonteCarloSimulationsForRankingCouples

has super-classes
Ranking Related Parameterc
has members
number of monte carlo simulations for ranking couples 10000ni

Observational Data Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ObservationalDataSource

A structured data repository containing data not directly related with drug safety that can be used for Pharmacovigilance Sugnal detection. Typical examples are EHRs (excluding clinical narratives in free-text form) and administrative claims databases.

has super-classes
Signal Sourcec
has sub-classes
Administrative Claims Databasec, Electronic Health Recordc
is in domain of
hasObservationTimedp, hasPopulationdp
has members
o s i mni, o s i m2ni

Original Bayesian Confidence Propagation Neural Network Originalc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Bayesian_Confidence_Propagation_Neural_Network_Original

has super-classes
Bayesian Confidence Propagation Neural Networkc

Original Gamma Poisson Shrinkagec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#GammaPoissonShrinkageOriginal

has super-classes
Gamma Poisson Shrinkage based Signal Detection Methodc

Original Proportional Reporting Ratio Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ProportionalReportingRatioSignalDetectionMethodOriginal

has super-classes
Proportional Reporting Ratio based Methodc

Original Reporting Odds Ratio Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ReportingOddsRatioMethodOriginal

has super-classes
Reporting Odds Ratio based Methodc

Outcomes To Includec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OutcomesToInclude

has super-classes
Parameterc
has members
outcomes to include all occurrencesni, outcomes to include first occurrenceni, outcomes to include first occurrence after exposureni

Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Parameter

A configurable option that is available for the instantiation and execution of a Signal Detection Method.

Examples: “Time at Risk”, “Decision rule for signal generation”.

is equivalent to
isAvailableForop some Signal Detection Methodc
has sub-classes
Apply Leopard Filtering For Protopathic Biasc, Case-Control Matching Strategyc, Comparator Populationc, Control Related Parameterc, Covariate Related Parameterc, Decision Related Parameterc, Exposures To Includec, Include All Drugs In A Multivariate Analysisc, Include Index Date In Time At Riskc, Minimum Number Of Notifications For A Couple To Be Potentially Considered As A Pharmacovigilance Signalc, Nesting Within Population With The Indication Of The Target Drugc, Outcomes To Includec, Prior Related Parameterc, Propensity Score Related Parameterc, Ranking Related Parameterc, Statistic Of Interest Mid-P-Valuesc, Stratification Parameterc, Study Designc, TROCc, TROC Thresholdc, Time At Riskc, Value Of The Tested Odds Ratioc, Value Of The Tested Riskc
is in domain of
hasDefaultValuedp, isAvailableForop, isSetForop
is in range of
hasParameterValueop, offersop
is disjoint with
Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Performance Metricc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PerformanceMetric

Measure for assessing the effectiveness of Signal Detectors.

Examples: “Area Under the Curve (AUC)”, “False Positive Rate”, “F-score”.

is in domain of
isSupportedByop
is in range of
supportsop
has members
a f r average false positivesni, a u c area under curveni, f p r false positive rateni, f scoreni, i c information componentni, i r r incidence rate ratio with mantel haenszel adjustment over age by gender stratani, longitudinal gamma poisson shrinkerni, m a p mean average precisionni, m g p s multi item gamma poisson shrinkerni, o r odds ratio with mantel haenszel adjustment by age and genderni, o r unadjusted odds rationi, o r unadjusted odds ratio from univariate logistic regression predicting outcome from exposureni, p r r proportional reporting rationi, p s propensity score adjustment using 20 strata as indicator variables in logistic regression outcome modelni, p s propensity score adjustment using 5 strata as indicator variables in logistic regression outcome modelni, p s propensity score adjustment using propensity score as continuous variable in logistic regression outcome modelni, p s propensity score stratification using mantel haenszel adjustment over 20 stratani, p s propensity score stratification using mantel haenszel adjustment over 5 stratani, r o r reporting odds rationi, r r reporting rationi
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Period Prior To Exposure In Expected Calculationc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PeriodPriorToExposureInExpectedCalculation

has super-classes
Prior Related Parameterc
has sub-classes
Use One Day Prior To Exposure In Expected Calculationc, Use One Month Prior To Exposure In Expected Calculationc

Pharmacovigilance Signalc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PhVSignal

(Computational) Pharmacovigilance Signal

A “Drug - Health Outcome” pair indicating a possible causal relation among the two parts, generated within an Analysis Experiment by one or more Signal Detectors. A Pharmacovigilance Signal may be validated by Reference Sources and it can be accompanied by data from Supporting Evidence Sources.

Example: (Drug:Vioxx – Health Outcome:Acute Myocardial Infarction) is result of Analysis Experiment:AB456, generated by Signal Detector:BCPNN_45 and Signal Detector:MGPS_103, validated by Reference Source:Epocrates and accompanied by Supporting Evidence Source:ChemIDPlus data.

is equivalent to
(isGeneratedByop some Signal Detectorc) and (is result ofop some Analysis Experimentc) and (concernsop only Drugc) and (concernsop only Health Outcomec)
is in domain of
is result ofop, isGeneratedByop, isValidatedByop
is in range of
generatesop, results inop, validatesop
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Prior Distributionc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PriorDistribution

has super-classes
Prior Related Parameterc
has members
prior distribution laplaceni, prior distribution normalni

Prior Parameters Chosenc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PriorParametersChosen

has super-classes
Prior Related Parameterc
has members
prior parameters chosen n u l lni

Prior Parameters Initialization Vectorc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PriorParametersInitializationVector

has super-classes
Prior Related Parameterc
has members
prior parameters initialization vector α1 0.2 β1 0.06 α2 1.4 β2 1.8 w 0.1ni

Propensity Score Related Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PropensityScoreRelatedParameter

has super-classes
Parameterc
has sub-classes
Propensity Score Covariate Selection Strategyc, Propensity Score Trimmingc

Propensity Score Trimmingc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PropensityScoreTrimming

has super-classes
Propensity Score Related Parameterc
has members
propensity score trimming noneni, propensity score trimming trim lower 5 percent from the comparator group and the upper 5 percent from the target groupni

Proportional Reporting Ratio based Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ProportionalReportingRatioMethod

has super-classes
Disproportionality based Signal Detection Methodc
has sub-classes
Original Proportional Reporting Ratio Signal Detection Methodc, Proportional Reporting Ratio Method Extended To The Multiple Comparison Frameworkc

Proportional Reporting Ratio Method Extended To The Multiple Comparison Frameworkc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ProportionalReportingRatioMethodExtendedToTheMultipleComparisonFramework

has super-classes
Proportional Reporting Ratio based Methodc

Ranking Criterionc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RankingCriterion

A feature that is used to sort (and implicitly filter) the potential Pharmacovigilance Signals generated in the scope of an Analysis Experiment. This class is specialized into two types, Domain-specific Ranking Critertion and Computation Ranking Criterion. Examples are provided for each type.

has sub-classes
Computational Ranking Criterionc, Domain-specific Ranking Criterionc
is in range of
uses ranking criterionop
is disjoint with
Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Ranking Related Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RankingRelatedParameter

has super-classes
Parameterc
has sub-classes
Monte Carlo Simulation For Ranking Couplesc, Number Of Monte Carlo Simulations For Ranking Couplesc, Statistic Used For Ranking The Couplesc

Reference Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ReferenceSource

An information repository that is used for validating the novelty of a potential Pharmacovigilance Signal.

Examples: “Epocrates”, “SIDER”, “UpToDate”.

has super-classes
validatesop some Pharmacovigilance Signalc
is in domain of
validatesop
is in range of
isValidatedByop
has members
epocratesni, s i d e rni
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Reporting Fisher’s Exact Test Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ReportingFishersExactTestSignalDetectionMethod

has super-classes
Disproportionality based Signal Detection Methodc

Reporting Odds Ratio based Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ReportingOddsRatioMethod

has super-classes
Disproportionality based Signal Detection Methodc
has sub-classes
Original Reporting Odds Ratio Methodc, Reporting Odds Ratio Method Extended To The Multiple Comparison Frameworkc

Reporting Odds Ratio Method Extended To The Multiple Comparison Frameworkc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ReportingOddsRatioMethodExtendedToTheMultipleComparisonFramework

has super-classes
Reporting Odds Ratio based Methodc

Required Observation Time Prior To Exposurec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RequiredObservationTimePriorToExposure

has super-classes
Prior Related Parameterc
has members
required observation time prior to exposure 180dni, required observation time prior to exposure 365dni, required observation time prior to exposure noneni

Required Observation Time Prior To Outcomec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RequiredObservationTimePriorToOutcome

has super-classes
Prior Related Parameterc
has members
required observation time prior to outcome 180dni, required observation time prior to outcome 30dni

Self-Controlled Case Series Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SelfControlledCaseSeriesSignalDetectionMethod

has super-classes
Self-Controlled Signal Detection Methodc
has members
o m o p s c c sni

Self-Controlled Cohort Design Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SelfControlledCohortDesignSignalDetectionMethod

has super-classes
Self-Controlled Signal Detection Methodc
has members
o m o p o sni

Self-Controlled Signal Detection Methodc back to ToC or Class ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#SelfControlledSignalDetectionMethod

has super-classes
Signal Detection Methodc
has sub-classes
Self-Controlled Case Series Signal Detection Methodc, Self-Controlled Cohort Design Signal Detection Methodc

Signal Detection Methodc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SignalDetectionMethod

Signal Detection Method

An implementation of a computational analysis method aiming to identify potential Pharmacovigilance Signals via its application to data originated from an appropriate type of Signal Source. A Signal Detection Method offers a set of Parameters for its fine-tuning that can be set.

Example: The BCPNN (Bayesian Confidence Propagation Neural Network) implementation contained in the PhViD Pharmacovigilance R Package (http://cran.r-project.org/web/packages/PhViD/)

is equivalent to
(canAnalyzeop some Signal Sourcec) and (isImplementedForop some Computing Environmentc) and (offersop some Parameterc)
has sub-classes
Case Control Signal Detection Methodc, Cohort Signal Detection Methodc, Disproportionality based Signal Detection Methodc, Self-Controlled Signal Detection Methodc
is in domain of
canAnalyzeop, hasAuthordp, hasImplementordp, is available atdp, isImplementedForop, offersop, supportsop
is in range of
executesop, isAppropriateForop, isAvailableForop, isSupportedByop
has members
o m o p i c t p dni
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Signal Detectorc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SignalDetector

The concrete runtime instantiation of a Signal Detection Method, according to specific Parameter values and input Dataset.

Example: The BCPNN (Bayesian Confidence Propagation Neural Network) implementation contained in the PhViD Pharmacovigilance R Package (http://cran.r-project.org/web/packages/PhViD/) with its default parameter values (RR0 = 1, MIN.n11 = 1, DECISION = 1, DECISION.THRES = 0.05, RANKSTAT = 1, MC = FALSE, NB.MC = 10000), applied on the French, national SRS database.

is equivalent to
instantiatesop only Signal Detection Methodc
is in domain of
generatesop, hasParameterValueop, is recommended forop
is in range of
hasRecommendedop, isGeneratedByop, isSetForop
has members
o s 4010002ni
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Sourcec, Supporting Evidence Sourcec, Userc

Signal Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SignalSource

A data repository that can be explored for Pharmacovigilance Signal detection. It has specific characteristics with respect to the type of data that it offers (structured/unstructured), the quality of its data, the type of Signal Detection Methods that can be used for its data analysis, etc.

Examples: Spontaneous Reporting System, Electronic Health Record system, Bibliographic database, Social media platform.

has super-classes
isAppropriateForop some Signal Detection Methodc
has sub-classes
Free-text Data Sourcec, Observational Data Sourcec, SRS Data Sourcec
is in domain of
contributesToop, isAppropriateForop
is in range of
canAnalyzeop, originatesFromop
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Userc

Social Media Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SocialMediaSource

has super-classes
Free-text Data Sourcec
has members
patients like meni, twitterni

SRS Data Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SRSDataSource

The dominant data source for Pharmacovigilance Signal detection. It comprises of reports voluntarily gathered by regulatory authorities and drug safety bodies for suspecious adverse drug events.

has super-classes
Signal Sourcec
has sub-classes
International SRSc, National SRSc

Statistic Of Interest Mid-P-Valuesc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MidPval

has super-classes
Parameterc

Statistic Used For Ranking The Couplesc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RankStat

has super-classes
Ranking Related Parameterc
has members
rank stat equals 1 posterior probability of null hypothesisni, rank stat equals 2 2.5 per cent quantile of the posterior distribution of i cni

Strategy To Stratify Datac back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#StrategyToStratifyData

has super-classes
Stratification Parameterc
has members
strategy to stratify data classify drug outcome co occurrences as exposed or unexposed and with or without outcomeni

Stratification Parameterc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#StratificationParameter

has super-classes
Parameterc
has sub-classes
Strategy To Stratify Datac, Stratify By Agec, Stratify By Genderc, Stratify By Yearc

Stratify By Agec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#StratifyByAge

has super-classes
Stratification Parameterc
has members
stratify by age noni, stratify by age yesni

Stratify By Genderc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#StratifyByGender

has super-classes
Stratification Parameterc
has members
stratify by gender noni, stratify by gender yesni

Stratify By Yearc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#StratifyByYear

has super-classes
Stratification Parameterc
has members
stratify by year noni

Study Designc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#StudyDesign

has super-classes
Parameterc
has members
study design cohort comparison with overall databaseni, study design self controlled cohortni

Supporting Evidence Sourcec back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SupportingEvidenceSource

Information source that can either facilitate the understanding, or complement the indications of Pharmacovigilance Signals generated by an Analysis Experiment.

Examples: “Drugbank”, “ChemIDPlus”.

has super-classes
isExploitedByop some Analysis Experimentc
is in domain of
isExploitedByop
is in range of
exploitsop
has members
drug bankni
is disjoint with
Analysis Criterionc, Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Userc

Threshold for Decisionc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DecisionThreshold

has super-classes
Decision Related Parameterc
has members
decision threshold equals 0.05ni

TROCc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#TROC

has super-classes
Parameterc
has members
t r o c f a l s eni, t r o c t r u eni

TROC Thresholdc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#TROCThreshold

has super-classes
Parameterc

Use Control Period In Expected Calculationc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseControlPeriodInExpectedCalculation

has super-classes
Control Related Parameterc
has members
use control period in expected calculation noni, use control period in expected calculation yesni

Use One Day Prior To Exposure In Expected Calculationc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseOneDayPriorToExposureInExpectedCalculation

has super-classes
Period Prior To Exposure In Expected Calculationc
has members
use one day prior to exposure in expected calculation noni, use one day prior to exposure in expected calculation yesni

Use One Month Prior To Exposure In Expected Calculationc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseOneMonthPriorToExposureInExpectedCalculation

has super-classes
Period Prior To Exposure In Expected Calculationc
has members
use one month prior to exposure in expected calculation noni, use one month prior to exposure in expected calculation yesni

Userc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#User

An Agent (Person / Organization) who is granted permission to setup Analysis Experiments.

has super-classes
sets upop some Analysis Experimentc
is in domain of
sets upop
is in range of
is set up byop
is disjoint with
Analysis Experimentc, Analysis Experiment Targetc, Computing Environmentc, Datasetc, Drugc, Health Outcomec, Parameterc, Performance Metricc, Pharmacovigilance Signalc, Ranking Criterionc, Reference Sourcec, Signal Detection Methodc, Signal Detectorc, Signal Sourcec, Supporting Evidence Sourcec

Value Of The Tested Odds Ratioc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OR0

has super-classes
Parameterc

Value Of The Tested Riskc back to ToC or Class ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RR0

has super-classes
Parameterc
has members
o r0 equals 1ni, r r0 equals 1ni

Object Properties

canAnalyzeop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#canAnalyze

has characteristics: irreflexive

has domain
Signal Detection Methodc
has range
Signal Sourcec
is inverse of
isAppropriateForop

concernsop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#concerns

containsop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#contains

has characteristics: irreflexive

has domain
Analysis Experimentc
has range
Analysis Criterionc
is inverse of
is defined forop

contributesToop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#contributesTo

has characteristics: irreflexive

has domain
Signal Sourcec
has range
Datasetc
is inverse of
originatesFromop

executesop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#executes

has characteristics: irreflexive

has domain
Computing Environmentc
has range
Signal Detection Methodc
is inverse of
isImplementedForop

exploitsop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#exploits

has characteristics: irreflexive

has domain
Analysis Experimentc
has range
Supporting Evidence Sourcec
is inverse of
isExploitedByop

generatesop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#generates

has characteristics: irreflexive

has domain
Signal Detectorc
has range
Pharmacovigilance Signalc
is inverse of
isGeneratedByop

hasParameterValueop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasParameterValue

has characteristics: irreflexive

has domain
Signal Detectorc
has range
Parameterc
is inverse of
isSetForop

hasRecommendedop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasRecommended

Refers to optimal SignalDetectionMethod Parameters per SignalSource and HealthOutcome resulted from empirical observations.

has characteristics: irreflexive

has domain
Health Outcomec or Signal Sourcec
has range
Signal Detectorc
is inverse of
is recommended forop

instantiatesop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#instantiates

has characteristics: irreflexive

is inverse of
isInstantiatedByop

is defined forop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isDefinedFor

has characteristics: irreflexive

has domain
Analysis Criterionc
has range
Analysis Experimentc
is inverse of
containsop

is recommended forop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isRecommendedFor

has domain
Signal Detectorc
has range
Health Outcomec or Signal Sourcec
is inverse of
hasRecommendedop

is result ofop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isResultOf

has characteristics: irreflexive

has domain
Pharmacovigilance Signalc
has range
Analysis Experimentc
is inverse of
results inop

is set up byop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isSetUpBy

has characteristics: irreflexive

has domain
Analysis Experimentc
has range
Userc
is inverse of
sets upop

isAppropriateForop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isAppropriateFor

has characteristics: irreflexive

has domain
Signal Sourcec
has range
Signal Detection Methodc
is inverse of
canAnalyzeop

isAvailableForop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isAvailableFor

has characteristics: irreflexive

has domain
Parameterc
has range
Signal Detection Methodc
is inverse of
offersop

isExploitedByop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isExploitedBy

has characteristics: irreflexive

has domain
Supporting Evidence Sourcec
has range
Analysis Experimentc
is inverse of
exploitsop

isGeneratedByop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isGeneratedBy

has characteristics: irreflexive

has domain
Pharmacovigilance Signalc
has range
Signal Detectorc
is inverse of
generatesop

isImplementedForop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isImplementedFor

has characteristics: irreflexive

has domain
Signal Detection Methodc
has range
Computing Environmentc
is inverse of
executesop

isInstantiatedByop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isInstantiatedBy

has characteristics: irreflexive

is inverse of
instantiatesop

isSetForop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isSetFor

has characteristics: irreflexive

has domain
Parameterc
has range
Signal Detectorc
is inverse of
hasParameterValueop

isSupportedByop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isSupportedBy

has characteristics: irreflexive

has domain
Performance Metricc
has range
Signal Detection Methodc
is inverse of
supportsop

isUsedInop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isUsedIn

has characteristics: irreflexive

is inverse of
usesop

isValidatedByop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isValidatedBy

has characteristics: irreflexive

has domain
Pharmacovigilance Signalc
has range
Reference Sourcec
is inverse of
validatesop

mayBeSetForop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#mayBeSetFor

has characteristics: irreflexive

has domain
Analysis Experiment Targetc
has range
Analysis Experimentc
is inverse of
mayHaveop

mayHaveop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#mayHave

has characteristics: irreflexive

has domain
Analysis Experimentc
has range
Analysis Experiment Targetc
is inverse of
mayBeSetForop

offersop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#offers

has characteristics: irreflexive

has domain
Signal Detection Methodc
has range
Parameterc
is inverse of
isAvailableForop

originatesFromop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#originatesFrom

has characteristics: irreflexive

has domain
Datasetc
has range
Signal Sourcec
is inverse of
contributesToop

results inop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#resultsIn

has characteristics: irreflexive

has domain
Analysis Experimentc
has range
Pharmacovigilance Signalc
is inverse of
is result ofop

sets upop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#setsUp

has characteristics: irreflexive

has domain
Userc
has range
Analysis Experimentc
is inverse of
is set up byop

supportsop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#supports

has characteristics: irreflexive

has domain
Signal Detection Methodc
has range
Performance Metricc
is inverse of
isSupportedByop

usesop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#uses

has characteristics: irreflexive

is inverse of
isUsedInop

uses ranking criterionop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#usesRankingCriterion

has domain
Analysis Experimentc
has range
Ranking Criterionc

validatesop back to ToC or Object Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#validates

has characteristics: irreflexive

has domain
Reference Sourcec
has range
Pharmacovigilance Signalc
is inverse of
isValidatedByop

Data Properties

encodesConditionsIndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#encodesConditionsIn

Options for encoding conditions, e.g. in ICD9.

has domain
Clinical Narrativec or Literature Sourcec or Observational Data Sourcec or SRS Data Sourcec
has range
{ "ICD9" }

encodesDrugsIndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#encodesDrugsIn

Options for encoding drugs in ATC and RxNorm systems.

has domain
Clinical Narrativec or Literature Sourcec or Observational Data Sourcec or SRS Data Sourcec
has range
{ "ATC" , "RxNorm" }

encodesObservationsIndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#encodesObservationsIn

Options for encoding conditions in the Logical Observation Identifiers Names and Codes and the Systematized Nomenclature of Human Medicine systems.

has domain
Clinical Narrativec or Literature Sourcec or Observational Data Sourcec or SRS Data Sourcec
has range
{ "LOINC" , "SNOMED-CT" }

encodesProceduresIndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#encodesProceduresIn

Options for procedures encoding in the Current Procedural Terminology, the Healthcare Common Procedure Coding System and ICD9.

has domain
Clinical Narrativec or Literature Sourcec or Observational Data Sourcec or SRS Data Sourcec
has range
{ "CPT" , "HCPCS" , "ICD9" , "LOINC" }

has performance metric valuedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasPerformanceMetricValue

has domain
Analysis Experimentc
has range
real

hasATCcodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasATCcode

Drug encoded in ATC.

has super-properties
hasCodedp
has domain
Drugc
has range
string

hasAuthordp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasAuthor

Refers to the Author of a Signal Detection Method (SignalDetectionMethod).

has domain
Signal Detection Methodc
has range
name

hasCodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasCode

has sub-properties
hasATCcodedp, hasICD10codedp, hasICD9codedp, hasMedDRAcodedp, hasOMOPcodedp, hasRXNORMcodedp, hasSNOMEDCTcodedp, hasUMLScodedp
has range
string

hasContributordp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasContributor

A Contributor of a Dataset, SignalDetectionMethod, SignalSource, or SupportingEvidence

has domain
Datasetc or Signal Detection Methodc or Signal Sourcec or Supporting Evidence Sourcec
has range
name

hasDefaultValuedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasDefaultValue

The default value for each Parameter offered by a Signal Detection Method (SignalDetectionMethod).

has domain
Parameterc
has range
string

hasDescriptiondp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasDescription

Denotes the Descritpion of a ComputingPlatform, Dataset, Metric, Parameter, SignalDetectionMethod, SignalSource, or SupportingEvidence

has domain
Computing Environmentc or Datasetc or Parameterc or Performance Metricc or Signal Detection Methodc or Signal Sourcec or Supporting Evidence Sourcec
has range
any u r i

hasFormatdp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasFormat

The format of a Dataset or a SupportingEvidence source, e.g. JSON, OMOP CDM v4.0, etc.

has domain
Datasetc or Supporting Evidence Sourcec
has range
{ "JSON" , "OMOP CDM v.2.0" , "OMOP CDM v1.0" , "OMOP CDM v3.0" , "OMOP CDM v4.0" }

hasICD10codedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasICD10code

HealthOutcome encoded in ICD10.

has super-properties
hasCodedp
has domain
Health Outcomec
has range
string

hasICD9codedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasICD9code

HealthOutcome encoded in ICD-9.

has super-properties
hasCodedp
has domain
Health Outcomec
has range
string

hasImplementordp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasImplementor

Refers to the implementor of a Signal Detection Method (SignalDetectionMethod).

has domain
Signal Detection Methodc
has range
name

hasLicensedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasLicense

Refers to the license for using a ComputingPlatform, Dataset, SignalDetectionMethod, SignalSource, or SupportingEvidence.

has domain
Computing Environmentc or Datasetc or Signal Detection Methodc or Signal Sourcec or Supporting Evidence Sourcec
has range
{ "Apache License Version 2.0" , "GPL-2" }

hasMedDRAcodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasMedDRAcode

HealthOutcome encoded in MedDRA.

has super-properties
hasCodedp
has domain
Health Outcomec
has range
string

hasObservationTimedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasObservationTime

The observation time of an observational signal source, which is typically expressed in person-years, e.g. 97.6 million person-years.

has domain
Observational Data Sourcec
has range
string

hasOMOPcodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasOMOPcode

HealthOutcome or Drug encoded in the OMOP dataset.

has super-properties
hasCodedp
has domain
Drugc or Health Outcomec
has range
string

hasPopulationdp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasPopulation

The Population contained in an Observational Data Source (ObservationalDataSource).

has domain
Observational Data Sourcec
has range
string

hasResultdp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasResult

Denotes the results of an Analysis Experiment (AnalysisExperiment).

has domain
Analysis Experimentc
has range
x m l literal

hasRXNORMcodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasRXNORMcode

Drug encoded in RxNorm.

has super-properties
hasCodedp
has domain
Drugc
has range
string

hasSNOMEDCTcodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasSNOMEDCTcode

HealthOutcome or Drug encoded in SNOMED-CT.

has super-properties
hasCodedp
has domain
Drugc or Health Outcomec
has range
string

hasUMLScodedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasUMLScode

HealthOutcome or Drug encoded in UMLS.

has super-properties
hasCodedp
has domain
Drugc or Health Outcomec
has range
string

hasValuedp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasValue

The value defined for a Criterion (AnalysisCriterion) of an Analysis Experiment (AnalysisExperiment).

has domain
Analysis Criterionc
has range
string

hasVersiondp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#hasVersion

The version of a SignalSource, a DataSource, a SignalDetectionMethod and/or a SupportingEvidence source.

has characteristics: functional

has domain
Datasetc or Reference Sourcec or Signal Detection Methodc or Signal Sourcec or Supporting Evidence Sourcec
has range
string

is available atdp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isAvailableAt

has domain
Signal Detection Methodc
has range
any u r i

isComputeddp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isComputed

Denotes whether the value of an Analysis Criterion (AnalysisCriterion) is user-defined or computationally inferred (e.g. via rules).

has domain
Analysis Criterionc
has range
boolean

isDocumentedIndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isDocumentedIn

Indicates a documentation resource for an AnalysisExperiment, a Dataset, a ReferenceSource, a SignalDetectionMethod, a SignalDetector, and/or a SupportingEvidence source.

has domain
Datasetc or Reference Sourcec or Signal Detection Methodc or Signal Detectorc or Signal Sourcec or Supporting Evidence Sourcec
has range
string

isUserDefineddp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#isUserDefined

Denotes whether the value of an Analysis Criterion (AnalysisCriterion) is user-defined or computationally inferred (e.g. via rules).

has domain
Analysis Criterionc
has range
boolean

wasLaunchedOndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#wasLaunchedOn

Denotes the timestamp of launching an Analysis Experiment (AnalysisExpriment).

has domain
Analysis Experimentc
has range
date time stamp

wasTerminatedOndp back to ToC or Data Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#wasTerminatedOn

Denotes the timestamp of terminating an Analysis Experiment (AnalysisExpriment).

has domain
Analysis Experimentc
has range
date time stamp

Named Individuals

a d r seriousnessni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ADRSeriousness

belongs to
Domain-specific Ranking Criterionc

a d r unexpectednessni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ADRUnexpectedness

belongs to
Domain-specific Ranking Criterionc

a f r average false positivesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#AFR_Average_False_Positives

belongs to
Performance Metricc

a u c area under curveni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#AUC_Area_Under_Curve

belongs to
Performance Metricc

acute liver injuryni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Acute_Liver_Injury

One of the 4 serious outcomes of interest examined in OMOP.

belongs to
Health Outcomec
has facts
hasICD9codedp "277.4, 570*, 572.2, 572.4*, 573*, 576.8, 782.4, 789.1*, 790.4*, 794.8*"^^string

acute myocardial infarctionni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Acute_Myocardial_Infarction

One of the 4 serious outcomes of interest examined in OMOP.

belongs to
Health Outcomec
has facts
hasICD9codedp ""410*","411.1","411.8*""

acute renal failureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Acute_Renal_Failure

One of the 4 serious outcomes of interest examined in OMOP.

belongs to
Health Outcomec
has facts
hasICD9codedp "584*"^^string
hasRecommendedop o s 4010002

additional covariates included in the propensity score model age and sexni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Additional_Covariates_Included_In_The_Propensity_Score_Model-Age_and_Sex

belongs to
Additional Covariates Included In The Propensity Score Modelc

additional covariates included in the propensity score model age and sex and index year and charlson index and number of drugs and number of visits and number of proceduresni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Additional_Covariates_Included_In_The_Propensity_Score_Model-Age_and_Sex_and_Index_Year_and_Charlson_Index_and_Number_Of_Drugs_and_Number_Of_Visits_and_Number_Of_Procedures

belongs to
Additional Covariates Included In The Propensity Score Modelc

additional covariates included in the propensity score model noneni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Additional_Covariates_Included_In_The_Propensity_Score_Model-None

belongs to
Additional Covariates Included In The Propensity Score Modelc

apply leopard filtering for protopathic bias noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Apply_Leopard_Filtering_For_Protopathic_Bias-No

belongs to
Apply Leopard Filtering For Protopathic Biasc

apply leopard filtering for protopathic bias yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Apply_Leopard_Filtering_For_Protopathic_Bias-Yes

belongs to
Apply Leopard Filtering For Protopathic Biasc

c++ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#C++

belongs to
Computing Environmentc

case control matching strategy age and sexni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Case_Control_Matching_Strategy-Age_and_Sex

belongs to
Case-Control Matching Strategyc

case control matching strategy age and sex and visit within 180dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Case_Control_Matching_Strategy-Age_and_Sex_and_Visit_Within_180d

belongs to
Case-Control Matching Strategyc

case control matching strategy age and sex and visit within 30dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Case_Control_Matching_Strategy-Age_and_Sex_and_Visit_Within_30d

belongs to
Case-Control Matching Strategyc

control period 1080d to 361d before exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period--1080d_To_-361d_Before_Exposure_Start

belongs to
Control Periodc

control period 180d prior to exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period-180d_Prior_To_Exposure_Start

belongs to
Control Periodc

control period 180d to 1d before exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period--180d_To_-1d_Before_Exposure_Start

belongs to
Control Periodc

control period 30d prior to exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period-30d_Prior_To_Exposure_Start

belongs to
Control Periodc

control period 30d to 1d before exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period--30d_To_-1d_Before_Exposure_Start

belongs to
Control Periodc

control period 365d prior to exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period-365d_Prior_To_Exposure_Start

belongs to
Control Periodc

control period 810d to 361d before exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period--810d_To_-361d_Before_Exposure_Start

belongs to
Control Periodc

control period all time prior to exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period-All_Time_Prior_To_Exposure_Start

belongs to
Control Periodc

control period length of exposure+30dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period-Length_Of_Exposure+30d

belongs to
Control Periodc

control period undefinedni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Control_Period-Undefined

belongs to
Control Periodc

covariate eligibility window 180d prior to exposureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Eligibility_Window-180d_Prior_To_Exposure

belongs to
Covariate Eligibility Windowc

covariate eligibility window 30d prior to exposureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Eligibility_Window-30d_Prior_To_Exposure

belongs to
Covariate Eligibility Windowc

covariate eligibility window all time prior to exposureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Eligibility_Window-All_Time_Prior_To_Exposure

belongs to
Covariate Eligibility Windowc

covariate eligibility window noneni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Eligibility_Window-None

belongs to
Covariate Eligibility Windowc

covariate selection algorithm additional parameters 500 top confounders from among 200 most prevalent covariates in each dimension that occur in at least 100 personsni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Selection_Algorithm_Additional_Parameters-500_Top_Confounders_From_Among_200_Most_Prevalent_Covariates_In_Each_Dimension_That_Occur_In_At_Least_100_Persons

belongs to
Covariate Selection Algorithm Additional Parametersc

covariate selection algorithm additional parameters 500 top confounders from among 500 most prevalent covariates in each dimension that occur in at least 100 personsni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Selection_Algorithm_Additional_Parameters-500_Top_Confounders_From_Among_500_Most_Prevalent_Covariates_In_Each_Dimension_That_Occur_In_At_Least_100_Persons

belongs to
Covariate Selection Algorithm Additional Parametersc

covariate selection algorithm additional parameters laplace prior distribution with variance equals 1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Selection_Algorithm_Additional_Parameters-Laplace_Prior_Distribution_With_Variance_equals_1

belongs to
Covariate Selection Algorithm Additional Parametersc

covariate selection algorithm additional parameters noneni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Covariate_Selection_Algorithm_Additional_Parameters-None

belongs to
Covariate Selection Algorithm Additional Parametersc

decision equals 1 f d rni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Decision_equals_1_FDR

belongs to
Decision Rule For The Signal Generationc

decision equals 2 number of signalsni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Decision_equals_2_Number_Of_Signals

belongs to
Decision Rule For The Signal Generationc

decision equals 3 rank statni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Decision_equals_3_RankStat

belongs to
Decision Rule For The Signal Generationc

decision threshold equals 0.05ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DecisionThreshold_equals_0.05

belongs to
Threshold for Decisionc

dimensions to include as potential covariates drugs and conditionsni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Dimensions_To_Include_As_Potential_Covariates-Drugs_and_Conditions

belongs to
Dimensions To Include As Potential Covariatesc

dimensions to include as potential covariates drugs conditions and proceduresni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Dimensions_To_Include_As_Potential_Covariates-Drugs_Conditions_and_Procedures

belongs to
Dimensions To Include As Potential Covariatesc

dimensions to include as potential covariates drugs onlyni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Dimensions_To_Include_As_Potential_Covariates-Drugs_Only

belongs to
Dimensions To Include As Potential Covariatesc

dimensions to include as potential covariates noneni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Dimensions_To_Include_As_Potential_Covariates-None

belongs to
Dimensions To Include As Potential Covariatesc

drug bankni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#DrugBank

The DrugBank database (http://www.drugbank.ca/) is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

belongs to
Supporting Evidence Sourcec

epocratesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Epocrates

Refers to this resource: http://www.epocrates.com/

belongs to
Reference Sourcec

eu dra vigilanceni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#EuDraVigilance

The EuDraVigilance spontaneous reporting system: http://eudravigilance.ema.europa.eu/human/index.asp

belongs to
International SRSc

events due to newer drugsni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#EventsDueToNewerDrugs

belongs to
Domain-specific Ranking Criterionc

events from mulitple countriesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#EventsFromMulitpleCountries

belongs to
Domain-specific Ranking Criterionc

exposures to include all occurrencesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Exposures_To_Include-All_Occurrences

belongs to
Exposures To Includec

exposures to include first occurrenceni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Exposures_To_Include-First_Occurrence

belongs to
Exposures To Includec

f a e r sni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#FAERS

The FDA Adverse Event Reporting System (FAERS) (formerly AERS): http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/default.htm

belongs to
National SRSc

f p r false positive rateni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#FPR_False_Positive_Rate

belongs to
Performance Metricc

f scoreni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#F-score

belongs to
Performance Metricc

gastrointestinal bleedingni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Gastrointestinal_Bleeding

One of the 4 serious outcomes of interest examined in OMOP.

belongs to
Health Outcomec
has facts
hasMedDRAcodedp "10000212 10000218 10000221 10000223 10000225 10000236 10000238 10000239 10002244 10002248 10002667 10003797 10006375 10008111 10008118 10008783 10008786 10010719 10013541 10013560 10013839 10013849 10013865 10014080 10015090 10015769 10015926 10016871 10017788 10017826 10017829 10017835 10017857 10017866 10017955 10018829 10018830 10018836 10018866 10018867 10018906 10018964 10018985 10019009 10019676 10022840 10022841 10027141 10027313 10027327 10027514 10030172 10030202 10030210 10030941 10034248 10034344 10034354 10034476 10034666 10034827 10035121 10036246 10036417 10036960 10037394 10038063 10038459 10038867 10041646 10042316 10042317 10042364 10043449 10043742 10045455 10046528 10046788 10047655 10047756 10051077 10053191 10053196 10055798 10055870 10057739 10061191 10061192 10061993 10062855 10063188 10065019"^^string
hasSNOMEDCTcodedp "102455002 102868004 10742003 10950002 111353003 111673001 111677000 11547003 11623000 12063002 122003 12274003 12355008 12441001 126941005 12847006 13507004 13937002 14255005 14460007 14936004 15115006 15238002 15720001 15902003 15970005 162373007 162815002 163987005 163990004 164187003 164200008 16694003 167800009 17067009 172.. 17593008 17615006 17709002 18367003 18503002 190305000 190306004 19031009 191304008 191308006 191314004 191328005 191330007 191331006 193287005 193475001 194179009 194862000 195155004 195160000 195162008 195165005 195167002 195173001 195174007 195176009 197092000 197222003 197472004 197473009 197475002 197627003 197698000 197699008 197700009 197701008 197702001 197703006 197704000 197705004 197706003 197938001 197939009 197940006 197941005 197942003 197973004 197974005 198645000 198656000 198706000 198719001 198745005 198757001 198887000 198888005 198889002 198890006 198891005 198892003 198893008 198894002 198903000 198904006 198905007 198906008 198907004 198916000 198917009 198918004 198919007 198920001 198921002 198922009 198923004 198924005 198925006 198926007 198927003 198928008 198929000 198931009 198932002 198933007 198934001 198935000 198937008 198938003 198939006 198940008 1994. 199576009 199577000 199578005 199579002 199995008 199996009 199997000 1C6.. 200014004 200015003 200016002 200018001 200019009 200020003 200021004 200022006 200023001 200024007 200025008 200026009 200027000 202394001 202402007 202403002 202404008 202405009 202406005 202407001 202408006 202409003 202410008 202411007 202412000 202413005 202414004 202415003 202416002 202417006 202418001 202419009 202420003 202421004 202422006 20276007 20407004 206191000 206194008 206202008 206244002 206249007 206304007 206395003 206396002 206397006 206398001 206399009 206401003 206404006 206405007 206406008 206408009 206410006 206411005 206412003 206414002 206415001 206416000 206421002 206423004 206425006 2066005 20908003 209930003 209931004 209932006 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864.11 865.01 865.11 866.01 866.11 86891002 86895006 87020000 87253004 87345009 8765009 87756006 87763006 87796008 87814002 88050005 88424000 88747000 89469000 89748001 90053006 90165008 90257004 90489006 91304009 95453001 95531001 95533003 95534009 95535005 95540002 95567008 95688008 981008 D312. J68z. K197. K286w K593. K595. K59y. K59z. L10y. L10zz l11.. L113. L360. N0917 Q2000 s62.."^^string
hasICD9codedp "719.19 719.14 719.11 719.13 719.17 719.15 719.18 719.16 719.12 719.10 786.3 380.31 376.32 379.23 372.72 363.61 363.6 621.4 362.43 363.72 363.62 360.43 456.20 998.11 998.12 998.1 772.12 772.11 772.13 772.10 772.14 767.11 997.02 866.11 864.11 866.01 865.11 865.01 864.01 791.2 784.7 784.8 777.3 782.7 772 770.3 719.1 374.81 362.81 432.0 432.1 423.0 666.1 666.2 666.0 656.0 665.7 640.83 640.93 640.91 640.81 640.80 640.90 624.5 599.72 608.82 599.71 599.70 569.3 578.9 578.1 578.0 535.31 533.41 533.21 533.00 530.21 535.51 533.40 533.01 535.21 535.11 535.71 535.61 535.41 535.01 533.61 533.60 533.20 532.2 532.4 532.0 532.6 666.24 666.04 666.00 666 665.74 665.70 666.10 666.22 666.20 666.12 666.02 666.14 665.72 772.6 772.4 665.71 772.3 772.2 772.1 762.1 656.01 656.03 656.00 640.9 640.8 639.1 638.1 641.93 641.81 641.31 641.13 641.11 641.10 641.80 635.10 641.90 641.83 641.30 635.11 641.91 641.33 635.12 599.7 562.12 562.02 562.13 562.03 641.3 636.10 636.1 634.1 641.9 641 635.1 634.10 641.8 641.1 640 637.11 629.0 637.12 636.12 636.11 626.7 626.6 634.12 634.11 627.0 620.7 627.1 626.9 626.8 626.5 626.3 626 596.7 602.1 578 568.81 377.42 534.41 534.40 534.01 532.40 531.4 531.01 531.0 530.82 534.61 534.60 534.4 533.4 533.0 532.41 532.20 531.60 531.20 534.6 534.2 534.00 534.0 534.21 534.20 533.6 532.61 532.60 532.21 532.01 532.00 531.61 531.41 531.40 531.21 531.00 533.2 531.6 531.2 456.0 459.0 432 431 430 287 287.2 246.3 078.6"^^string

i c information componentni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#IC_Information_Component

belongs to
Performance Metricc

i r r incidence rate ratio with mantel haenszel adjustment over age by gender stratani back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#IRR_Incidence_Rate_Ratio_With_Mantel_Haenszel_Adjustment_Over_Age_By_Gender_Strata

belongs to
Performance Metricc

include all drugs in a multivariate analysis noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_All_Drugs_In_A_Multivariate_Analysis-No

belongs to
Include All Drugs In A Multivariate Analysisc

include all drugs in a multivariate analysis yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_All_Drugs_In_A_Multivariate_Analysis-Yes

belongs to
Include All Drugs In A Multivariate Analysisc

include index date in control period noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_Index_Date_In_Control_Period-No

belongs to
Include Index Date In Control Periodc

include index date in control period undefinedni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_Index_Date_In_Control_Period-Undefined

belongs to
Include Index Date In Control Periodc

include index date in control period yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_Index_Date_In_Control_Period-Yes

belongs to
Include Index Date In Control Periodc

include index date in time at risk noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_Index_Date_In_Time_At_Risk-No

belongs to
Include Index Date In Time At Riskc

include index date in time at risk yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Include_Index_Date_In_Time_At_Risk-Yes

belongs to
Include Index Date In Time At Riskc

javani back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Java

The Java platform (Oracle).

belongs to
Computing Environmentc

larebni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Lareb

The Netherlands Pharmacovigilance Centre (Lareb): http://www.lareb.nl/?lang=en-GB

belongs to
National SRSc

longitudinal gamma poisson shrinkerni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Longitudinal_Gamma_Poisson_Shrinker

belongs to
Performance Metricc

m a p mean average precisionni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MAP_Mean_Average_Precision

belongs to
Performance Metricc

m g p s multi item gamma poisson shrinkerni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MGPS_Multi_Item_Gamma_Poisson_Shrinker

belongs to
Performance Metricc

m i n.n11 equals 1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MIN.n11_equals_1

belongs to
Minimum Number Of Notifications For A Couple To Be Potentially Considered As A Pharmacovigilance Signalc

matlabni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Matlab

The Matlab scientific computing software (MathWorks).

belongs to
Computing Environmentc

monte carlo simulation for ranking couples f a l s eni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MonteCarloSimulationForRankingCouples_FALSE

belongs to
Monte Carlo Simulation For Ranking Couplesc

monte carlo simulation for ranking couples t r u eni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#MonteCarloSimulationForRankingCouples_TRUE

belongs to
Monte Carlo Simulation For Ranking Couplesc

nesting within population with the indication of the target drug noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Nesting_Within_Population_With_The_Indication_Of_The_Target_Drug-No

belongs to
Nesting Within Population With The Indication Of The Target Drugc

nesting within population with the indication of the target drug yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Nesting_Within_Population_With_The_Indication_Of_The_Target_Drug-Yes

belongs to
Nesting Within Population With The Indication Of The Target Drugc

number of monte carlo simulations for ranking couples 10000ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#NumberOfMonteCarloSimulationsForRankingCouples_10000

belongs to
Number Of Monte Carlo Simulations For Ranking Couplesc

o m o p c c a eni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OMOP_CCAE

The MarketScan Commercial Claims and Encounters database employed by OMOP. Represents privately insured population and captures administrative claims with patient-level de-identified data from inpatient and outpatient visits and pharmacy claims of multiple insurance plans.

belongs to
Administrative Claims Databasec

o m o p c mni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OMOP_CM

Cohort Method

belongs to
Cohort Signal Detection Methodc
has facts
offersop additional covariates included in the propensity score model age and sex
offersop additional covariates included in the propensity score model age and sex and index year and charlson index and number of drugs and number of visits and number of procedures
offersop additional covariates included in the propensity score model none
offersop covariate eligibility window 180d prior to exposure
offersop covariate eligibility window 30d prior to exposure
offersop covariate eligibility window all time prior to exposure
offersop covariate eligibility window none
offersop covariate selection algorithm additional parameters 500 top confounders from among 200 most prevalent covariates in each dimension that occur in at least 100 persons
offersop covariate selection algorithm additional parameters 500 top confounders from among 500 most prevalent covariates in each dimension that occur in at least 100 persons
offersop covariate selection algorithm additional parameters laplace prior distribution with variance equals 1
offersop covariate selection algorithm additional parameters none
offersop dimensions to include as potential covariates drugs conditions and procedures
offersop dimensions to include as potential covariates drugs only
offersop dimensions to include as potential covariates drugs and conditions
offersop dimensions to include as potential covariates none
offersop nesting within population with the indication of the target drug no
offersop nesting within population with the indication of the target drug yes
supportsop o r unadjusted odds ratio from univariate logistic regression predicting outcome from exposure
supportsop p s propensity score adjustment using 20 strata as indicator variables in logistic regression outcome model
supportsop p s propensity score adjustment using 5 strata as indicator variables in logistic regression outcome model
supportsop p s propensity score adjustment using propensity score as continuous variable in logistic regression outcome model
supportsop p s propensity score stratification using mantel haenszel adjustment over 20 strata
supportsop p s propensity score stratification using mantel haenszel adjustment over 5 strata
offersop patients with a diagnosis for the indication of the target drug
offersop patients with a diagnosis for the indication of the target drug and at least one exposure to a drug known to be not associated with the outcome
offersop patients with exposure to any comparator drug which shares the same indication as the target drug but is not in the same pharmacologic class
offersop patients with exposure to most prevalent comparator drug which shares the same indication as the target drug but is not in the same pharmacologic class
offersop propensity score covariate selection strategy bayesian logistic regression using all available covariates
offersop propensity score covariate selection strategy exposure specific covariate selection algorithm identified by brookhart et al
offersop propensity score covariate selection strategy high dimensional propensity score covariate selection algorithm by schneeweiss et al
offersop propensity score covariate selection strategy no covariate adjustment
offersop propensity score trimming none
offersop propensity score trimming trim lower 5 percent from the comparator group and the upper 5 percent from the target group
offersop required observation time prior to exposure 180d
isImplementedForop s a s
offersop time at risk 30d from exposure start
offersop time at risk all time post exposure start
offersop time at risk length of exposure+30d

o m o p g e centricityni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OMOP_GE_Centricity

The GE Centricity employed by OMOP. The GE MQIC (Medical Quality Improvement Consortium) represents the group of providers who use the GE Centricity Electronic Medical Record and who contribute their data for secondary analytic use. The GE MQIC database reflects events in usual care, including patient problem lists, prescribing patterns and over-the-counter use (OTC) of medications, and other clinical observations as experienced in the ambulatory care setting.

belongs to
Electronic Health Recordc

o m o p m d c dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OMOP_MDCD

The MarketScan Multi-State Medicaid databased employed by OMOP. Contains administrative claims data for Medicaid enrollees from multiple states, including inpatient, outpatient, and pharmacy services.

belongs to
Administrative Claims Databasec

o m o p m d c rni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OMOP_MDCR

The MarketScan Multi-State Medicaid database employed by OMOP. Captures administrative claims for retirees with Medicare supplemental insurance paid by employers, including services provided under Medicare-covered payment, employer-paid portion, and any out- of-pocket expenses.

belongs to
Administrative Claims Databasec
has facts
hasRecommendedop o s 4010002

o m o p m s l rni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OMOP_MSLR

The MarketScan Lab Supplemental database employed by OMOP. Represents privately insured population that has at least one recorded laboratory value, with administrative claims from inpatient, outpatient, and pharmacy services supplemented by laboratory results.

belongs to
Administrative Claims Databasec

o r odds ratio with mantel haenszel adjustment by age and genderni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OR_Odds_Ratio_With_Mantel_Haenszel_Adjustment_By_Age_And_Gender

belongs to
Performance Metricc

o r unadjusted odds rationi back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OR_Unadjusted_Odds_Ratio

belongs to
Performance Metricc

o r unadjusted odds ratio from univariate logistic regression predicting outcome from exposureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OR_Unadjusted_Odds_Ratio_From_Univariate_Logistic_Regression_Predicting_Outcome_From_Exposure

belongs to
Performance Metricc

o r0 equals 1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OR0_equals_1

belongs to
Value Of The Tested Riskc

o s i mni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OSIM

Observational Medical Dataset Simulator

belongs to
Observational Data Sourcec

o s i m2ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#OSIM2

Enhanced Observational Medical Dataset Simulator

belongs to
Observational Data Sourcec
has facts
isAppropriateForop o m o p c c
isAppropriateForop o m o p c m
isAppropriateForop o m o p d p
isAppropriateForop o m o p i c t p d
isAppropriateForop o m o p l g p s
isAppropriateForop o m o p o s
isAppropriateForop o m o p s c c s

outcomes to include all occurrencesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Outcomes_To_Include-All_Occurrences

belongs to
Outcomes To Includec

outcomes to include first occurrenceni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Outcomes_To_Include-First_Occurrence

belongs to
Outcomes To Includec

outcomes to include first occurrence after exposureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Outcomes_To_Include-First_Occurrence_After_Exposure

belongs to
Outcomes To Includec

p r r proportional reporting rationi back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PRR_Proportional_Reporting_Ratio

belongs to
Performance Metricc

p s propensity score adjustment using 20 strata as indicator variables in logistic regression outcome modelni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PS_Propensity_Score_Adjustment_Using_20_Strata_As_Indicator_Variables_In_Logistic_Regression_Outcome_Model

belongs to
Performance Metricc

p s propensity score adjustment using 5 strata as indicator variables in logistic regression outcome modelni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PS_Propensity_Score_Adjustment_Using_5_Strata_As_Indicator_Variables_In_Logistic_Regression_Outcome_Model

belongs to
Performance Metricc

p s propensity score adjustment using propensity score as continuous variable in logistic regression outcome modelni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PS_Propensity_Score_Adjustment_Using_Propensity_Score_As_Continuous_Variable_In_Logistic_Regression_Outcome_Model

belongs to
Performance Metricc

p s propensity score stratification using mantel haenszel adjustment over 20 stratani back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PS_Propensity_Score_Stratification_Using_Mantel_Haenszel_Adjustment_Over_20_Strata

belongs to
Performance Metricc

p s propensity score stratification using mantel haenszel adjustment over 5 stratani back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PS_Propensity_Score_Stratification_Using_Mantel_Haenszel_Adjustment_Over_5_Strata

belongs to
Performance Metricc

patients like meni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PatientsLikeMe

A well known social networking platform for patients (http://www.patientslikeme.com/).

belongs to
Social Media Sourcec

patients with a diagnosis for the indication of the target drugni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Patients_With_A_Diagnosis_For_The_Indication_Of_The_Target_Drug

belongs to
Comparator Populationc

patients with a diagnosis for the indication of the target drug and at least one exposure to a drug known to be not associated with the outcomeni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Patients_With_A_Diagnosis_For_The_Indication_Of_The_Target_Drug_And_At_Least_One_Exposure_To_A_Drug_Known_To_Be_Not_Associated_With_The_Outcome

belongs to
Comparator Populationc

patients with exposure to any comparator drug which shares the same indication as the target drug but is not in the same pharmacologic classni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Patients_With_Exposure_To_Any_Comparator_Drug_Which_Shares_The_Same_Indication_As_The_Target_Drug_But_Is_Not_In_The_Same_Pharmacologic_Class

belongs to
Comparator Populationc

patients with exposure to most prevalent comparator drug which shares the same indication as the target drug but is not in the same pharmacologic classni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Patients_With_Exposure_To_Most_Prevalent_Comparator_Drug_Which_Shares_The_Same_Indication_As_The_Target_Drug_But_Is_Not_In_The_Same_Pharmacologic_Class

belongs to
Comparator Populationc

precision at kni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Precision_at_K

belongs to
Computational Ranking Criterionc

prior distribution laplaceni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Prior_Distribution-Laplace

belongs to
Prior Distributionc

prior distribution normalni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Prior_Distribution-Normal

belongs to
Prior Distributionc

prior parameters chosen n u l lni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PriorParametersChosen_NULL

belongs to
Prior Parameters Chosenc

prior parameters initialization vector α1 0.2 β1 0.06 α2 1.4 β2 1.8 w 0.1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PriorParametersInitializationVector_α1_0.2_β1_0.06_α2_1.4_β2_1.8_w_0.1

belongs to
Prior Parameters Initialization Vectorc

propensity score covariate selection strategy bayesian logistic regression using all available covariatesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Propensity_Score_Covariate_Selection_Strategy-Bayesian_Logistic_Regression_Using_All_Available_Covariates

belongs to
Propensity Score Covariate Selection Strategyc

propensity score covariate selection strategy exposure specific covariate selection algorithm identified by brookhart et alni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Propensity_Score_Covariate_Selection_Strategy-Exposure_Specific_Covariate_Selection_Algorithm_Identified_By_Brookhart_et_al

belongs to
Propensity Score Covariate Selection Strategyc

propensity score covariate selection strategy high dimensional propensity score covariate selection algorithm by schneeweiss et alni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Propensity_Score_Covariate_Selection_Strategy-High_Dimensional_Propensity_Score_Covariate_Selection_Algorithm_By_Schneeweiss_et_al

belongs to
Propensity Score Covariate Selection Strategyc

propensity score covariate selection strategy no covariate adjustmentni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Propensity_Score_Covariate_Selection_Strategy-No_Covariate_Adjustment

belongs to
Propensity Score Covariate Selection Strategyc

propensity score trimming noneni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Propensity_Score_Trimming-None

belongs to
Propensity Score Trimmingc

propensity score trimming trim lower 5 percent from the comparator group and the upper 5 percent from the target groupni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Propensity_Score_Trimming-Trim_Lower_5_percent_From_The_Comparator_Group_and_The_Upper_5_percent_From_The_Target_Group

belongs to
Propensity Score Trimmingc

pub medni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#PubMed

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites (http://www.ncbi.nlm.nih.gov/pubmed).

belongs to
Literature Sourcec

rni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#R

The R, open-source statistical software.

belongs to
Computing Environmentc

r o r reporting odds rationi back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#ROR_Reporting_Odds_Ratio

belongs to
Performance Metricc

r r reporting rationi back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RR_Reporting_Ratio

belongs to
Performance Metricc

r r0 equals 1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RR0_equals_1

belongs to
Value Of The Tested Riskc

rank stat equals 1 posterior probability of null hypothesisni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RankStat_equals_1_Posterior_Probability_Of_Null_Hypothesis

belongs to
Statistic Used For Ranking The Couplesc

rank stat equals 2 2.5 per cent quantile of the posterior distribution of i cni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RankStat_equals_2_2.5_Per_Cent_Quantile_Of_The_Posterior_Distribution_Of_IC

belongs to
Statistic Used For Ranking The Couplesc

rapidly increasing disproportionalityni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#RapidlyIncreasingDisproportionality

belongs to
Domain-specific Ranking Criterionc

recall at kni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Recall_at_K

belongs to
Computational Ranking Criterionc

required observation time prior to exposure 180dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Required_Observation_Time_Prior_To_Exposure-180d

belongs to
Required Observation Time Prior To Exposurec

required observation time prior to exposure 365dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Required_Observation_Time_Prior_To_Exposure-365d

belongs to
Required Observation Time Prior To Exposurec

required observation time prior to exposure noneni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Required_Observation_Time_Prior_To_Exposure-None

belongs to
Required Observation Time Prior To Exposurec

required observation time prior to outcome 180dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Required_Observation_Time_Prior_To_Outcome-180d

belongs to
Required Observation Time Prior To Outcomec

required observation time prior to outcome 30dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Required_Observation_Time_Prior_To_Outcome-30d

belongs to
Required Observation Time Prior To Outcomec

s a sni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SAS

The SAS statisical software.

belongs to
Computing Environmentc

s i d e rni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#SIDER

SIDER (http://sideeffects.embl.de/) contains information on marketed medicines and their recorded adverse drug reactions. The information is extracted from public documents and package inserts. The available information includes side effect frequency, drug and side effect classifications as well as links to further information, for example drug–target relations.

belongs to
Reference Sourcec

scopusni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Scopus

Scopus (http://www.scopus.com/) is a large abstract and citation database of peer-reviewed literature, featuring tools to track, analyze and visualize research.

belongs to
Literature Sourcec

strategy to stratify data classify drug outcome co occurrences as exposed or unexposed and with or without outcomeni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Strategy_To_Stratify_Data-Classify_Drug_Outcome_Co-occurrences_As_Exposed_or_Unexposed_and_With_or_Without_Outcome

belongs to
Strategy To Stratify Datac

stratify by age noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Stratify_By_Age-No

belongs to
Stratify By Agec

stratify by age yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Stratify_By_Age-Yes

belongs to
Stratify By Agec

stratify by gender noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Stratify_By_Gender-No

belongs to
Stratify By Genderc

stratify by gender yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Stratify_By_Gender-Yes

belongs to
Stratify By Genderc

stratify by year noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Stratify-By_Year-No

belongs to
Stratify By Yearc

study design cohort comparison with overall databaseni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Study_Design-Cohort_Comparison_With_Overall_Database

belongs to
Study Designc

study design self controlled cohortni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Study_Design-Self_Controlled_Cohort

belongs to
Study Designc

t r o c f a l s eni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#TROC_FALSE

belongs to
TROCc

t r o c t r u eni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#TROC_TRUE

belongs to
TROCc

time at risk 30d from exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-30d_From_Exposure_Start

belongs to
Time At Riskc

time at risk 360d from exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-360d_From_Exposure_Start

belongs to
Time At Riskc

time at risk 60d from exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-60d_From_Exposure_Start

belongs to
Time At Riskc

time at risk all time post exposure startni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-All_Time_Post_Exposure_Start

belongs to
Time At Riskc

time at risk length of exposureni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-Length_Of_Exposure

belongs to
Time At Riskc

time at risk length of exposure+30dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-Length_Of_Exposure+30d

belongs to
Time At Riskc

time at risk length of exposure+60dni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Time_At_Risk-Length_Of_Exposure+60d

belongs to
Time At Riskc

twitterni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Twitter

The widely used microblogging social networking platform (https://twitter.com/).

belongs to
Social Media Sourcec

up to 10 controls per caseni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Up_To_10_Controls_Per_Case

belongs to
Controls PerCasec

up to 100 controls per caseni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Up_To_100_Controls_Per_Case

belongs to
Controls PerCasec

use control period in expected calculation noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Use_Control_Period_In_Expected_Calculation-No

belongs to
Use Control Period In Expected Calculationc

use control period in expected calculation yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Use_Control_Period_In_Expected_Calculation-Yes

belongs to
Use Control Period In Expected Calculationc

use one day prior to exposure in expected calculation noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseOneDayPriorToExposureInExpectedCalculation-No

belongs to
Use One Day Prior To Exposure In Expected Calculationc

use one day prior to exposure in expected calculation yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseOneDayPriorToExposureInExpectedCalculation-Yes

belongs to
Use One Day Prior To Exposure In Expected Calculationc

use one month prior to exposure in expected calculation noni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseOneMonthPriorToExposureInExpectedCalculation-No

belongs to
Use One Month Prior To Exposure In Expected Calculationc

use one month prior to exposure in expected calculation yesni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#UseOneMonthPriorToExposureInExpectedCalculation-Yes

belongs to
Use One Month Prior To Exposure In Expected Calculationc

variance of the prior determined through cross validationni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Variance_Of_The_Prior-Determined_Through_Cross_Validation

belongs to
Variance Of The Priorc

variance of the prior pre defined at 0.01ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Variance_Of_The_Prior-Pre-defined_At_0.01

belongs to
Variance Of The Priorc

variance of the prior pre defined at 0.1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Variance_Of_The_Prior-Pre-defined_At_0.1

belongs to
Variance Of The Priorc

variance of the prior pre defined at 1ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Variance_Of_The_Prior-Pre-defined_At_1

belongs to
Variance Of The Priorc

variance of the prior pre defined at 10ni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#Variance_Of_The_Prior-Pre-defined_At_10

belongs to
Variance Of The Priorc

vigi baseni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#VigiBase

The WHO-UMC international drug safety database: http://www.umc-products.com/DynPage.aspx?id=73590&mn1=1107&mn2=1132

belongs to
International SRSc

yellow cardsni back to ToC or Named Individual ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#YellowCards

The UK on-line reporting system (the Yellow Card Scheme): http://yellowcard.mhra.gov.uk/

belongs to
National SRSc

Annotation Properties

contact emailap back to ToC or Annotation Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#contactEmail

contact emailap back to ToC or Annotation Property ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#contactEmail

has range
any u r i

creatorap back to ToC or Annotation Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#creator

creatorap back to ToC or Annotation Property ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#creator

has range
string

formatap back to ToC or Annotation Property ToC

IRI: http://safer-project.eu/SignalDetectorsOntology.owl#format

formatap back to ToC or Annotation Property ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#format

has range
string

languageap back to ToC or Annotation Property ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#language

has range
string

project homepageap back to ToC or Annotation Property ToC

IRI: http://www.co-ode.org/ontologies/ont.owl#projectHomepage

has range
any u r i

Namespace Declarations back to ToC

default namespace
http://safer-project.eu/SignalDetectorsOntology.owl#
SignalDetectorsOntology
http://safer-project.eu/SignalDetectorsOntology.owl#
ont
http://www.co-ode.org/ontologies/ont.owl#
owl
http://www.w3.org/2002/07/owl#
rdf
http://www.w3.org/1999/02/22-rdf-syntax-ns#
rdfs
http://www.w3.org/2000/01/rdf-schema#
safer-project-eu
http://safer-project.eu/
signaldetectorsontology-owl
http://safer-project.eu/SignalDetectorsOntology.owl/
xsd
http://www.w3.org/2001/XMLSchema#

This HTML document was obtained by processing the OWL ontology source code through LODE, Live OWL Documentation Environment, developed by Silvio Peroni.